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Heat Waves Rolling In

Photo credit: Steve Marcus/Las Vegas Sun via AP

By Leila Waid.

The beginning of summer has already brought immense heat waves throughout the world. Countries in Southeast Asia, such as India and Thailand, already had extreme heat waves in April—with UNICEF stating that the extreme temperatures posed a risk to 243 million children. In the Southwest U.S., June has also seen record-breaking extreme temperatures in early June. With the summer just beginning, how many more heatwaves will the world endure this season, and how many individuals will be at risk?

Heat waves are a significant public health issue because of the variety of health issues they pose. They are a prescient environmental justice issue because, due to climate change, the temperatures will keep climbing to unbearable levels. A study using modeling techniques has found that heat waves will become more extreme and longer-lasting in the latter half of the 21st century. An alarming finding from another study forecasts that “the limit for survivability may be reached at the end of the twenty-first century in many regions of the world” because the combination of high heat and humidity levels (referred to as the wet-bulb temperature) can pose extreme danger to human health.   

One way that heat waves impact human health is by increasing the risk of cardiovascular disease. Heart disease is already the number one cause of death in the U.S. According to the American Health Association, close to 50% of the American population has some form of heart disease. This finding means that half of Americans are at an even more increased risk from heat waves. Along with impacting those who already have heart issues, heat waves are also associated with the development of heart disease – with epidemiological studies showcasing that increased temperatures can lead to the development of ischemic heart disease.

Increased temperature places undue stress on the body, and these changes can cause “imbalances in the autonomic control of the heart, increase local arterial pressures, induce systemic inflammation, and impair clotting responses.” Thus, heat waves place those with pre-existing heart disease in increased danger and also increase the risk of heart disease development in the rest of the population. One study modeled how climate change will impact cardiovascular rates in the future and found that death from heart disease could increase from 162% to 233%. Currently, extreme heat causes an estimated 1,651 deaths annually from heart disease. The study projects that this number could increase anywhere from 4,320 to 5,491 deaths by the mid-21st century.  

As with most aspects of health, the impacts are not felt equally across the populations due to societal factors. For example, those with lower socioeconomic status face worse health outcomes during heat waves. One study examined whether insurance status played a role in heat-induced heart attacks and found that it was a critical factor in individuals’ health outcomes. Based in New York, the study found that individuals without health insurance – a stand-in for socioeconomic status (SES) – had a higher risk of myocardial infarction (heart attacks) during extreme heat even than those with health insurance. Another study conducted in Hong Kong found similar results – older individuals with lower SES were more likely to be admitted to the hospital during heat waves than those with higher SES.

Climate change continues to cause record-breaking heat waves year after year, and thus, we need to be aware of all of the risks these temperatures pose to our health. At an individual level, it is essential to understand what factors can place you at risk and to avoid outside activity, if possible, during these extreme temperatures. At a community level, we must look out for one another. For example, this summer, check up on your elderly family members and neighbors and be aware of signs of heat exhaustion and heat strokes in others so that you can provide assistance in case of emergencies. And at a societal level, keep fighting for and supporting climate change policies!

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Health Effects of PFAS in Drinking Water

The glass is always... we're screwed comic.
Image credit: Jim Morissey

By Leila Waid.

As a research project for a university course, I conducted a literature review and systematic analysis of the health effects of PFAS in drinking water. This blog post contains a highlight and broad overview of the health effects discovered.

The systematic analysis included 44 observational epidemiological studies focused on PFAS-contaminated water as the exposure and adverse health effects as the outcome of interest. (For inquiries, references to individual studies, or any other information about the information about the systematic review study, email info@chej.org).

The results:

PFAS in drinking water is associated with a variety of different health effects. However, it is important to note that the results included here do not prove causation. In other words, the studies cannot prove that PFAS caused these health issues, only that an increase in PFAS exposure is associated with these health effects.

  • Cardiovascular health: increase in “bad” cholesterol, triglyceride lipids, blood pressure, hypertensive pregnancy disorder.
  • Hormonal health (endocrine system): impaired thyroid function, disruption in the growth hormone IGF-1 in children, lower levels of estradiol and testosterone, increase in Poly-Cystic Ovary Syndrome, fibroids, and testicular cancer.
  • Immune health: increase in adverse health effects from COVID-19, disruption in inflammation production, lower immune cell count and production, increase in ulcerative colitis (stomach ulcers).
  • Urinary system health: kidney function impairment, kidney cancer, bladder cancer
  • Digestive system: esophageal cancer.
  • Neonatal (infant) health: lower birthweight and small for gestational age.
  • PFAS has also been found to cause epigenetic changes, which is a process through which our environment impacts how our genes are expressed. In other words, it does not change the actual DNA structure, but how the body reads the DNA sequence. Specifically, PFAS is associated with DNA methylation (a process through which chemicals attach to a DNA chain and turn a specific gene on or off. This process affects how the gene is read).
  • Mortality: exposure to PFAS associated with all-cause mortality, as well as mortalities from liver cancer, cerebrovascular disease, diabetes, myocardial infarction, kidney cancer, breast cancer, and Alzheimer’s disease.
  • Neurological system: developmental language disorder.
  • Skeletal system: increase in bone fractures (hip, proximal humeral, and distal forearm fractures).
  • Non-regional specific: mesothelioma cancer (affects tissues around organs), increase in multi-morbidity (multiple chronic morbidities occurring at the same time).
  • Mental health: increased anxiety, financial stress around health issues, emotional distress due to worrying about living in PFAS-contaminated region. Also, PFAS was associated with an increase in behavioral problems among children. 

It is important to note that all the adverse health effects discussed above were found from observational studies on human health, not animal or in vitro (cell) studies. Although the findings cannot prove causation, they still paint an alarming picture for human health. The results showcase that urgent and robust policy action is needed at the federal and state levels to protect our waterways from PFAS contamination. This situation is critical because almost half (45%) of all tap water systems in the U.S. have PFAS contamination. And one study found that an estimated 97% of all Americans have PFAS in their blood streams.