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Toxic Tuesdays

Glyphosate Risks

Toxic Tuesdays

CHEJ highlights several toxic chemicals and the communities fighting to keep their citizens safe from harm.

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Glyphosate Risks

Glyphosate is a chemical found in weed killer products like RoundUpTM used on farms and home lawns. Because of its effectiveness, glyphosate has become the most widely used herbicide in the world. People who work with these products and people who live near farms where they are used can get exposed to glyphosate through the air. The International Agency for Research on Cancer (IARC) has concluded that glyphosate exposure probably causes blood cancers. 81% of American adults and children have detectable concentrations of glyphosate in their urine. While much is still unknown about the potential health risks of glyphosate exposure, two recently published studies illuminate how big a concern it may be for both workers and the public.

One study aimed at assessing the potential cancer risk posed to farmers who work with glyphosate-containing herbicides. The study used data from the Agricultural Health Study (AHS), which collected biological samples from private and commercial pesticide applicators in Iowa and North Carolina from 1993-1997. The study analyzed AHS participants who were male, above the age of 50, had no blood disorders, and had not been diagnosed with cancer, which created a sample of 1,681 people. The researchers analyzed the DNA of these participants to look for the loss of large portions of DNA in the Y chromosome. Significant loss of DNA portions can have a massive effect on how the body’s cells function and have been linked to increased risk for cancer. Losses of large portions of DNA in the Y chromosome have been specifically linked to blood cancers like those that may be caused by glyphosate exposure.

In the study, 21% of participants had lost large portions of the DNA in their Y chromosome in some of their cells. Statistical analysis found that using glyphosate-containing pesticides for either a longer period or with more intensity were both associated with more DNA loss in the Y chromosome. While these findings do not prove that occupational exposure to glyphosate causes cancer, they provide important biological evidence that glyphosate exposure can cause the kinds of largescale changes in DNA that are associated with cancer. It is the first study of agricultural workers to show this association between glyphosate and DNA loss.

A second study sought the extent of glyphosate exposure among people who live near farms where glyphosate is used. Some studies have shown that glyphosate exposure during pregnancy is associated with reduced fetal growth and pre-term birth. Thus, this study focused on measuring glyphosate levels of pregnant people in Idaho who live near farms that use glyphosate. The study included 40 participants in Idaho who were in their first trimester of pregnancy in 2021. Researchers collected weekly urine samples from participants until delivery. Half of participants lived near farms (less than 0.5 kilometers from a farm) and half lived far from farms (more than 0.5 kilometers from a farm). About two-thirds of both groups had detectable concentrations of glyphosate in their urine.

For participants living near farms, the frequency and concentration of glyphosate detection in urine increased significantly during the pesticide spray season (from May to August) compared to the non-spray season. This change did not occur in participants living far from farms, indicating that increased exposure to glyphosate was likely a result of pesticide spraying. While these findings do not directly track the health effects on pregnant participants or their infants, it is important biological evidence that agricultural use of glyphosate exposes nearby residents. It is the first study to demonstrate that residential proximity to farms using glyphosate is associated with increased glyphosate in the body.

These two studies demonstrate that glyphosate may pose risks to both workers and the public. CHEJ has previously written about the uses and health risks of glyphosate here.

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Pyrethrins

Pyrethrins are a class of naturally occurring compounds derived from chrysanthemum flowers. They have been

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Toxic Tuesdays

Endometrial Cancer & Pesticides​

Toxic Tuesdays

CHEJ highlights several toxic chemicals and the communities fighting to keep their citizens safe from harm.

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Endometrial Cancer & Pesticides

Endometrial cancer is an increasingly common form of cancer in developed countries. There are both genetic and environmental risk factors associated with the development of endometrial cancer, and changing the environmental risk factors may be the easiest way of reducing the incidence of endometrial cancer. Pesticides – mixtures of chemicals used in agriculture to protect crop growth – are known to cause certain cancers, but it is unclear if they can cause endometrial cancer. A recent study in Spain found that occupational exposure to pesticides is associated with endometrial cancer.

The study took place from 2017 to 2021, with researchers administering a questionnaire to 180 women with endometrial cancer. To create a control group to compare these women to, researchers also administered the questionnaire to 218 women admitted to hospitals who didn’t have endometrial cancer. The researchers asked about lifetime occupational history, demographic information, tobacco consumption, physical activity, family history of diseases, reproductive factors, and other information.

The researchers systematically coded all respondents’ occupations based on a job exposure matrix (JEM) for Spanish working conditions. A JEM is a list of occupations that provides estimated exposures to a variety of harmful chemicals for each one, respectively. Using a JEM allowed the researchers to estimate respondents’ exposure to pesticides based on their occupations. This was a clever way of creating a history of each person’s occupational exposure to pesticides, whereas collecting their current environmental or biological data would not have been able to capture their accumulated lifetime exposure. The three categories of job titles considered to be exposed to pesticides were: agricultural, poultry, and livestock activities; cleaning staff; and manufacturing and lumber industries. Using the JEM, and estimated occupational exposure to pesticides, the researchers performed statistical tests to determine if occupational exposure was associated with endometrial cancer.

Occupational exposure to pesticides was associated with two times greater odds of developing endometrial cancer than not having occupational exposure. Exposures that happened further in the past were associated with cancer, as were exposures that happened before the age of 32. Surprisingly, increased cumulative exposure was not associated with endometrial cancer. Working in agricultural, poultry, and livestock activities was associated with four times greater odds of developing endometrial cancer. Working as cleaning staff was not associated with endometrial cancer, which could be because the intensity and frequency of exposure in these jobs may be lower.

Cancers like endometrial cancer can be difficult to study because it can take a long time for the disease to develop after someone gets exposed to a cancerous chemical. Once the disease develops, collecting environmental or biological samples from the patient’s time of exposure is not possible. This study got around these limitations by using a job exposure matrix to estimate exposure to pesticides throughout women’s entire working lives. Of course, these exposures are only estimates, their use of personal protective equipment in each job was unknown, and researchers could not know what other potential cancer-causing chemicals respondents may have been exposed to.

Regardless of the limitations, this study is valuable because diseases related to women’s reproductive systems are less studied compared to many other diseases. It is also the first study to show an association between occupational pesticide exposure and endometrial cancer.

New regulations and increased use of personal protective equipment may explain why exposures further in the past were more associated with endometrial cancer. However, the results of this study demonstrate that these improvements may not be enough to keep workers safe when they come into contact with pesticides. Endometrial cancer can now be added to a growing list of diseases associated with pesticides, and more should be done to protect workers and the public from these chemicals.

For more information, CHEJ has previously written about chemicals that have been used in pesticides and herbicides such as atrazine, benzene, ethylbenzene, glyphosate, and pentachlorophenol.

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Pyrethrins

Pyrethrins are a class of naturally occurring compounds derived from chrysanthemum flowers. They have been

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Toxic Tuesdays

Ethlybenzene

Toxic Tuesdays

CHEJ highlights several toxic chemicals and the communities fighting to keep their citizens safe from harm.

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Ethylbenzene

Ethylbenzene is a colorless flammable liquid that comes from coal tar and petroleum. It is primarily used to synthesize chemicals that are used in plastics. Ethylbenzene can also be used in fuels and injection fluid, which is used to release natural gas from the ground. It has industrial uses in solvents and pesticides and can also be found in consumer products like paint and ink. Spills and waste disposal from factories that use ethylbenzene often enter the water and soil. Burning oil, gas, coal, and cigarettes can release ethylbenzene into the air. Inhalation of this contaminated air is the primary path of exposure.

Brief inhalation of air contaminated with ethylbenzene can cause eye and throat irritation and dizziness. Little else is known about the human health effects of short- or long-term exposure to the chemical. In scientific studies of laboratory animals, short-term exposure has been shown to cause permanent hearing loss; long-term exposure has been shown to cause kidney damage too.

The International Agency for Research on Cancer says that ethylbenzene is a possible human carcinogen, meaning it might cause cancer in humans. While more studies could be done to better understand the effects of exposure on humans, it is clear ethylbenzene is a biologically dangerous chemical, and there should be protections in place to ensure that people are not exposed to it.

 

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Pyrethrins

Pyrethrins are a class of naturally occurring compounds derived from chrysanthemum flowers. They have been

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Climate change making farm work a dangerous job

A report released the week of December 9, 2019 shows how climate change creates a great threat to farmworkers. The report focuses on two main threats to workers: pesticide exposure and heat stress conditions. Read More.

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EPA Will Not Ban Pesticide Linked to Brain Damage in Infants

Exposure to the pesticide chlorpyrifos has been linked to brain damage in infants and children. California banned it earlier this year, and last August a federal court ordered EPA to ban the chemical. EPA announced last week that it would not ban the pesticide, citing insufficient data. <Read more>
 
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Garry Broome / Associated Press
Garry Broome / Associated Press
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California to ban controversial pesticide, citing effects on child brain development

California, one of the nation’s largest agricultural states, announced plans Wednesday to ban the widely used pesticide chlorpyrifos linked to neurological problems in infants and children even as federal regulators have allowed the product to remain on the market. Read more.

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Backyard Talk News Archive

Happy Valentines Day

heartBy Teresa Mills
Today as I opened my Valentines Day card I was immediately transported to a place that I had forgotten existed.  It was a small  neighborhood where the streets were lined with beautiful majestic trees with leaves just beginning to bud.  The sweet smell of spring was in the air.
As I walked along the streets, I did see an occasional patch of dandelions.  It was plain to see that the neighborhood children loved these tiny flowers as I found several rings and necklaces made from these golden flowers.  As I picked up one of these tiny rings, I noticed that these childhood treasures were the only things discarded on the sidewalks.  The lawns seemed natural; I wanted to take off my shoes and run through the yards like I did when I was young.
In this place I found adults sitting on their porches drinking tea out of beautiful handpainted porcelain cups, no throwaways here.  (Remember when houses had porches.)
As I passed by a group of neighbors talking about their upcoming neighborhood picnic, I could hear how excited they were, and it arose such a warm feeling in me that took me back to my childhood. Back to the days when teenagers would get so upset because everyone in town knew your business and kids knew they could not get away with anything, ya just knew someone would tell your mom.
When I looked up all I saw was a blue sky with an occasional puffy cloud.  I felt I could see forever.
Just as I took a deep breath and closed my eyes, I realized I had broken this wonderful spell I was under.  When I opened my eyes I was back to reality.  The sweet smells became the all too familiar heavy odorous smells of industry.  I once had an elected official tell me that the smells showed the community was prospering.  Really?
The so-called perfect manicured lawn I see every day are not natural they are lawns doused with man-made chemicals.  Have you ever look at one of those little signs they put in your yard after it has been sprayed?
Have a heart today, wish your neighbor a Happy Valentines day or just a good day. Today people go for months or even years without talking to their neighbors.  What a shame.
I tried to open my Valentines Card again to see if it would once again be transported back to my childhood days.  But my card turned out to be just a Happy Valentines Day Card from my loving husband.  But oh I wish I could go back to those carefree days.  Think of your childhood and have a beautiful Valentines Day.
 

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Backyard Talk

Positives and Pitfalls of EPA’s Pesticide Ruling

Between long hours, low pay and hazardous working conditions, farmworkers – many of whom are from minority and low-income communities – bear incredible health costs in order to sustain our country’s food supply. Pesticide exposure is one of the main occupational hazards of farm work, with both short-term health effects that can lead to lost days of work and school and hefty medical bills, and increased long-term risks of cancer and neurological problems. The EPA states that agricultural workers report between 1800 and 3000 pesticide exposure limits annually. It has been 22 years since the EPA last updated their agricultural Worker Protection Standard, and so the recently enacted changes, which more stringently protect farmworker health, are a welcome development, but are they enough?

The changes increase the frequency of pesticide handling training from every five years to a more robust annual requirement, which will include information about take-home exposures from dirty clothing and boots. They also establish “buffer zones” to protect workers from over-exposure to fumes and sprays. The regulations also set an age limit of eighteen for the handling and mixing of pesticides. Previously, there were no restrictions on children’s exposure to pesticides. The Farmworker Association of Florida wrote that the protections “bring farmworkers more in parity with health and safety regulations already covering workers in most other professions in the United States.”

https://www.youtube.com/watch?v=p0PMYSirxlY&feature=youtu.be

The regulations have been met with praise but also criticism from advocacy groups. While age limits and training requirements have been celebrated, many have commented that the new rules do not require workers to undergo routine medical monitoring for pesticide exposures, a protective measure that is required in both California and Washington.

Some advocates have also identified language barriers in communicating about the risks of pesticides, which typically have warning labels in English. “More than 80 percent of workers in the “salad bowls” of Salinas, Calif. or Yuma, Ariz., are Hispanic,” NPR reported in 2013. A further step for protecting worker safety would be to require making bilingual information available for pesticide products, which the recently updated regulations do not require. While advocacy group Farmworker Justice celebrated the regulations, Virginia Ruiz, the group’s director of occupational and environmental health, also stated in 2013 that “without bilingual labeling, today’s Spanish-speaking agricultural workforce is at great risk for pesticide exposure.”

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Gosia Wozniacka/AP - From NPR

Another pitfall of the regulations rests at the intersection of environmental justice and our nation’s debate over immigration reform. Paola Betchart of the Worker Justice Center of New York stated in an interview with North Country Public Radio that many farmworker illnesses go unreported because of the undocumented status of workers, who are fearful they will be deported if they seek medical attention. Justice for our nation’s farmworkers will require us to address much more than just pesticide exposure levels, but the new regulations are certainly a positive – and long-awaited – first step.


Learn more about farmworker exposures to pesticides here.

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